This Article presents the case against genetic enhancement. It begins with a critique of Fukuyama’s highly publicized work on enhancement. It then reconstructs the case for regulation, arguing that enhancement will undermine the most basic and universal sources of meaning and well-being in human life. The Article pays special attention to the law and economics scholarship, holding that the economic method will not detect certain types of harm to the human genome. The essay concludes with a policy solution that will preserve the benefits of genetic therapy while avoiding the harms of genetic enhancement.